Hypertension medications can be divided into the categories listed below, based on how they work. For some people, a combination of two or more drugs may be needed to keep their blood pressure under control. If one drug doesn’t lower your blood pressure enough, another might do the job. There are many different types of blood pressure medications with different modes of action. But many also take medication to treat their condition. Some people find that lifestyle changes alone are enough to control their high blood pressure.